# FOXO4

Main Functions and Mechanisms of Action of FOXO4

• Blocking the "Survival Signals" of Senescent Cells: Senescent cells highly express the FOXO4 protein, which tightly binds to the apoptosis protein p53, preventing senescent cells from undergoing normal cell death (apoptosis). This leads to the accumulation of toxic inflammatory factors in the body.

• Precise Targeted Clearance: Researchers have designed a FOXO4-DRI peptide that competitively binds to p53, releasing FOXO4's binding and prompting senescent cells to actively undergo programmed cell death without harming normal healthy cells.

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