# SS-31

SS-31's Main Efficacy and Mechanism of Action

• Cardiolipin Binding: SS-31 can specifically bind to cardiolipin on the inner mitochondrial membrane, stabilizing the mitochondrial membrane structure.

• Improved Energy Metabolism (ATP Synthesis): It can fix the protein complex of the electron transport chain, prevent oxidative damage to cardiolipin, enhance respiratory complex activity, and thus improve ATP (energy) production efficiency.

• Antioxidant and Reduction of Reactive Oxygen Species (ROS): It can effectively reduce the level of ROS in mitochondria and cells, alleviating oxidative stress.

• Anti-inflammatory and Apoptosis Inhibition: In models such as acute kidney injury, it has been found to inhibit the expression of downstream NLRP3 inflammasomes, reducing apoptosis.

• Research and Clinical Application Directions: Current research mainly focuses on diseases related to mitochondrial dysfunction, such as heart failure, age-related muscle weakness, acute kidney injury, and rare diseases such as Barth syndrome.

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